SignatureCare Emergency Center 281-258-4351

SignatureCare Emergency Room – Houston, TX

Read Our Message To All Patients.

SignatureCare Emergency Center Stands Against Racism. Read More.

THIS IS NOT A TESTING CENTER. While we are required to evaluate everyone that come in for an evaluation, we are requesting that if you do not have symptoms or any reason to suspect exposure to COVID-19, please DO NOT sign-up for any appointments using the link below, and give those folks that are sick the opportunity to sign-up. You can always come in to our ERs and register to be evaluated without a registration fee for your emergencies on-site, however you may have to wait at the location. Because we are an emergency room, wait-times are often unpredictable.
Please do not sign-up for these reasons: Job clearance, Travel clearance, Day-care clearance, “re-test” to see if you are negative now after testing positive once.
Get your COVID-19 evaluation appointment here.

We Have Rapid COVID-19 Test

We have three types of COVID tests available for evaluation including Antigen, Antibody and Molecular (PCR) tests. Get more details about our COVID-19 tests.

– Wait-time in the ER may be longer
– We can also bill your insurance
– COVID-19 evaluation available 24/7

Complete this short form and bring it with you to the ER. Please check in with Registration Desk first before standing in line.

If you’ve visited our location already, Get more COVID-19 instructions and information.

SignatureCare Emergency Center Locations Now Medicare Certified and Enrolled. Call your nearest ER for more details.

SignatureCare Emergency Center locations across Texas are now accredited to bill Active Military Plans. Call your nearest ER for details.

How SignatureCare Emergency Center Protects You from COVID-19

During this COVID-19 pandemic, SignatureCare Emergency Center takes extra steps to keep the community safe when they visit our ER. Everyone including our staff, patients and their family members wear masks while in the facility. We also enforce hand hygiene for everyone. All our facilities are equipped with HEPA air filtration, every room and furniture is sanitized before patients enter the rooms, all linens are changed for every new patient, and we have a negative pressure isolation room available should one be needed. At SignatureCare Emergency Center, we go beyond the minimum standard required for the safety of our patients and staff. We do COVID-19 and antibody evaluation.

24-Hour Emergency Room

Each 24-hour ER is staffed with board-certified physicians, licensed nurses and trained support staff. Wait times are 10 minutes or less. Our ER services include a Full Lab, CT Scan and X-rays and each emergency center is equipped to treat most minor and major medical emergencies for adults and children (pediatrics).

Get Social with SignatureCare Emergency Center - Open 24 Hours!

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coronavirus information
CDC Coronavirus COVID19 Self Checker

All SignatureCare Emergency Center locations can perform COVID-19 emergency evaluations. We conduct rapid 15-minute Antigen Test, Molecular (PCR) Test, and Antibody Test for COVID-19 at all our facilities. We are open 24/7/365. Get more information.


This is a freestanding emergency medical care facility. When a patient receives an emergency evaluation at this facility, there is an associated facility fee and a physician fee charged for the medical care provided to the patient in addition to any testing and other services provided. COVID Antigen swab (87635) is charged at $175.00.

SignatureCare ER Locations

Houston-Memorial City

1014 Wirt Rd.
Houston, TX 77055
Tel: 832-834-6414


1007 Westheimer Rd.
Houston, TX 77006
Tel: 281- 479-3293


11103 Westheimer Rd.
Houston, TX 77042
Tel: 832-708-3651


1925 E. TC Jester Blvd.
Houston, TX 77008
Tel: 832-742-0072


5835 Hwy. 6 North
Houston TX 77084
Tel: 281-861-0937


5413 South Rice Avenue
Houston, TX 77081
Tel: 713-669-9900

Houston-Cypress/FM 1960

5003 Cypress Creek Pkwy
Houston, TX 77069
Tel: 281-213-5444

Mission Bend/Sugar Land

8910 Hwy. 6 South
Houston, TX 77083
Tel: 281-258-4351

Stafford, TX

3531 Main Street
Stafford, TX 77477
Tel: 281-410-2009

Texarkana, TX

2001 Mall Drive
Texarkana, TX 75503
Tel: 903-306-2126

Odessa, TX

2731 N. Grandview Ave.
Odessa, TX 79762
Tel: 432-366-0945

Paris, TX

3055 NE Loop 286
Paris, TX 75460
Tel: 903-739-2116

 College Station/Bryan, TX

1512 Texas Ave. S, Ste 500
College Station, TX 77840
Tel: 979- 213-5728

Austin, TX

5701 W. Slaughter Ln, G101
Austin, TX 78749
Tel: 512-651-5787

Killeen, TX

800 W. Central TX Expy
Killeen, TX 76541
Tel: 254-220-4117

Midland, TX

5409 West Wadley Ave.
Midland, TX 79707
Tel: 432-699-2601

Lewisville, TX

1596 W Main St.
Lewisville, TX 75067
Tel: 972-829-4862

Pflugerville, TX

21315 TX-130 Bldg. 4
Pflugerville, TX 78660
Tel: 512-354-4134

Dripping Springs, TX

333 East Highway 290 #350
Dripping Springs, TX 78620
Tel: 512-436-0929

Humble, TX

35324 Atascocita Road, Suite T Humble, TX 77346
Tel: 281-213-5063

24-Hour Emergency Care

When you need emergency medical care, our ER doctors are available 24 hours to take care of you. We treat you like family. SignatureCare Emergency Center treats most minor and major emergencies, and wait times are typically 10 minutes or less.

Houston, TX Emergency Room, SignatureCare Emergency Center

Freestanding 24-Hour Emergency Room Near You!

10 Minutes or Less Wait for ER Physician.

SignatureCare Emergency Centers' 24-hour emergency rooms are located near your home in Houston and other Texas cities. Our freestanding emergency room (ER) is fully equipped to meet all your family's emergency medical needs. Patients are seen in 10 minutes or less by licensed physicians and trained emergency room registered nurses.

Our emergency rooms are equipped to treat a wide range of medical emergencies. We function like your local hospital ER, without the wait.

Average wait time to see a medical doctor in our emergency clinic is 10 minutes or less. Our 24-hour ER provides emergency treatment for most immediate medical care needs for adults and children. We have convenient emergency room locations throughout Texas including nine in the Houston area. See our emergency rooms in Houston, TX.

Fastest Growing 24-Hour ER in Texas

We are the fastest growing emergency centers in Texas and we offer 24-hour emergency care services including lab work,  X-ray and CT scan.  Each ER is equipped to treat most minor or major medical emergencies.

If your treatment requires overnight observation - our freestanding emergency centers have state-of-the-art observation rooms and highly trained medical staff. Our ER doctors are available on site 24 hours. This will assure you have the best medical care.

There is an Emergency Room near you

Visit a SignatureCare Emergency Center ER near you today.  We treat children, infants and adults, and bill most insurance plans. We also see self - pay patients and you will always receive a free medical evaluation prior to any treatment. We treat dental emergencies when your dentist is closed and also provide emergency HIV - STD testing and treatment, based on physician's determination and diagnosis.

SignatureCare Emergency Center- "Your Care is Our Signature"

SignatureCare Emergency Center News and Videos

SignatureCare Emergency Center Achieves Medicare Certification –

SignatureCare Emergency CenterSignatureCare Emergency Center is pleased to announce that all of its emergency room locations except South Austin and Pflugerville are certified to treat all Medicare and Medicare Advantage participants, and Killeen, College Station/Bryan, Midland, Odessa, Paris, and Copperfield (Northwest Houston area), TX are accredited to bill active military insurance plans. South Austin and Pflugerville are in the process of being Medicare certified. Get more details here.

SignatureCare Emergency Center Expands to Pflugerville, TX –

Pflugerville Emergency CenterSignatureCare Emergency Center, your friendly neighborhood 24-hour Texas emergency room is expanding to the Austin suburb of Pflugerville, TX. The new emergency center will serve residents of Pflugerville, Hutto, Round Rock, San Marcos and other nearby Texas cities. It is set to open early June, 2020, and will be located on the southeast corner of SH 130 and Gattis School Road at 21315 N SH 130, Bldg.4, Pflugerville, TX.

SignatureCare Emergency Center Salutes All Nurses on National Nurses Week 2020 –

Emergency Room NursesAt SignatureCare Emergency Center, we celebrate Emergency Nurses Week, and will like to extend our thanks to all nurses this National Nurses Week 2020. From the Senior Leadership team, THANK YOU for all you do and for giving our patients exceptional care. We appreciate all of you! See all the freebies for nurses here.

We are hiring for our new ER in Pflugerville, TX –

Pflugerville ER Job fairSignatureCare Emergency Center is opening a new 24-hour emergency room (ER) in Pflugerville, TX 78660 and we are hiring for various positions. We are holding a job fair on Tuesday, May 12, 2020 from 10:00 AM to 4:00 PM (CST) at the ER location at 21315 N. SH 130, Bldg. 4, Pflugerville, TX 78660. Please join us. Bring a copy of your resume and your best smile! Complete job fair information is here.

SignatureCare Emergency Center Kids Coloring Contest –

Signaturecare Emergency Center Coloring ContestColoring is a great way for little ones to pass the time during the coronavirus shut down. We are giving kids ages 6-12 years old a chance to express their creative genius with a coloring contest and a chance to win some really cool prices including one year of Disney+, Netflix Digital Gift Card and Amazon Digital Gift Card. Enroll today!

UW Freshman Wins SignatureCare Emergency Center’s 2020 Spring Semester Scholarship –

Caitlin RichardsonCaitlin Richardson, a University of Washington MEDEX Physician Assistant (PA) program freshman has won SignatureCare Emergency Center’s 2020 Spring Semester Scholarship. The $1,000 scholarship, awarded biannually to U.S. students who show passion and commitment to the medical and healthcare field, is aimed at helping the students pay tuition and other college-related expenses. Read about Cait here.

For our videos and more news stories, please go to our News and Videos page. Learn everything you need to know about coronavirus (COVID-19).