News Flash! SignatureCare Emergency Center is now administering Eli Lilly’s Bamlanivimab (LY-CoV555) COVID-19 treatment to patients. Get details here or call your nearest SignatureCare ER 24/7.

Directions to the Closest Emergency Room

We have multiple emergency room locations throughout Texas to serve you and your family. Our emergency rooms are located in the Houston area including (Houston-Memorial City, Houston-Montrose, Houston-Westchase, Houston-Heights, Houston-Copperfield, Houston-Bellaire, Houston-Cypress/FM 1960, Mission Bend/Sugar Land, and Stafford), Texarkana, Odessa, Paris, College Station/Bryan, Austin, Killeen, Midland, Lewisville, Pflugerville, Plano, Spring, and Atascocita/Humble, TX.

Our newest ER location in Spring, TX is now open.

All our emergency rooms are open 24/7. We have board-certified emergency medicine physicians on-site 24 hours, and state-of-the-art equipment. We accept most medical insurance plans* and have little to no wait times in our ERs.

To find your closest emergency room, click the links below for a Google Map direction or just call the nearest emergency center 24/7.

*Please call the nearest emergency room to confirm that we accept your medical insurance plan before visiting the ER.

SignatureCare Emergency Center - 24-hour Emergency Rooms

Houston-Memorial City

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1014 Wirt Rd.
Houston, TX 77055
Tel: 832-834-6414


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3209 Montrose Blvd.
Houston, TX 77006
Tel: 281- 479-3293


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11103 Westheimer Rd.
Houston, TX 77042
Tel: 832-708-3651


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1925 E. TC Jester Blvd.
Houston, TX 77008
Tel: 832-742-0072


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5835 Hwy. 6 North
Houston TX 77084
Tel: 281-861-0937


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5413 South Rice Avenue
Houston, TX 77081
Tel: 713-669-9900

Houston-Cypress/FM 1960

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5003 Cypress Creek Pkwy
Houston, TX 77069
Tel: 281-213-5444

Mission Bend-Sugar Land

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8910 Hwy. 6 South
Houston, TX 77083
Tel: 281-258-4351


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3531 Main Street
Stafford, TX 77477
Tel: 281-410-2009


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2001 Mall Drive
Texarkana, TX 75503
Tel: 903-306-2126


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2731 N. Grandview Ave.
Odessa, TX 79762
Tel: 432-366-0945


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3055 NE Loop 286
Paris, TX 75460
Tel: 903-739-2116

 College Station/Bryan

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1512 Texas Ave. S, Ste 500
College Station, TX 77840
Tel: 979- 213-5728


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5701 W. Slaughter Ln, G101
Austin, TX 78749
Tel: 512-651-5787


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800 W. Central TX Expy
Killeen, TX 76541
Tel: 254-220-4117


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5409 West Wadley Ave.
Midland, TX 79707
Tel: 432-699-2601


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1596 W Main St.
Lewisville, TX 75067
Tel: 972-829-4862



21315 TX-130 Bldg. 4
Pflugerville, TX 78660
Tel: 512-354-4134



5324 Atascocita Road
Suite T
Humble, TX 77346
Tel: 281-213-5063



621 Rayford Road
Spring, TX 77386
Tel: 281-973-0122



3670 Hwy 121
Plano, TX 75025
Tel: 972-829-4866

SignatureCare Emergency Center emergency rooms function like hospital ER without the long wait. Our typical emergency room wait time is 10 minutes or less. Our board-certified physicians can treat most medical emergencies from minor cuts or stitches to broken bones and abdominal pain.

We can run blood tests, CT Scans, MRIs, and X- Rays, in addition to HIV and STD testing. We accept most medical insurance health plans except Medicaid and Medicare. Visit our 24-hour emergency rooms for workers comp injuries and motor vehicle accidents.

If you need additional information or to speak with one of our emergency room trained specialists 24 hours a day, please call your nearest emergency center 24/7/365.